Pharmacokinetics in rabbits blood after intranasal administration of borneolhydroxypropyl-β-cyclodextrin inclusion

Objective To study the pharmacokinetics in rabbits blood after intranasal administration of borneol-hydroxypropyl-β-cyclodextrin inclusion. Methods After intranasal administration, GC method was used to determine contents of borneol in plasma, and the pharmacokinetic parameters were calculated by the software of DAS 2.1.1. Results Pharmacokinetics of borneolhydroxypropyl-β-cyclodextrin inclusion in rabbits fitted with the two compartment model, and Cmax was 8.162 mg/L, tmax was 1 min. Conclusion Pharmacokinetic characters of borneol in rabbits are confirmed which can provide reference for further study of preparation.