Expression and significance of Fas/FasL of preeclampsia patient′s placenta and decidua basalis

Objective To detect expression levels of Fas/FasL of placenta and decidua cells in preeclamptic patients and explore pathogenesis of gestational hypertension.Methods By immunohistochemistry,Fas/FasL expressions of placenta and decidua basalis from 34 patients in preeclampsia group and 16 placenta and decidua basalis in normal pregnancy group were analyzed by semi-quantitative analysis.Results The main expression of Fas protein lied in cell membrane and cytoplasm.Compared with the normal pregnancy group,Fas of placental trophoblast cells in preeclampsia group colored severely than that in the normal pregnancy group,and the color strengthened with the exacerbations of preeclampsia.The main expression of FasL protein lied in cytoplasm and cell membrane.Compared with the normal pregnancy group,FasL of preeclampsia trophoblast cells colored weakly with the preeclampsia exacerbations.Conclusion he increase of Fas,the decrease of FasL and disproportionality of Fas/FasL in placental trophoblastic of preeclampsia patients and pathogenesis of gestational hypertension were related.The abnormal expression of Fas/FasL system from the trophoblast cells and decidua might play an important role in the pathogenesis of preeclampsia which would provide new direction for clinical treatment of hypertensive disorders in pregnancy.