2007•Xinjiang Yike Daxue xuebaoRequires access

The expression of CD4~+CD25~+ T cells in the patients with rheumatoid arthritis

Wei Li

Abstract

Objective:To investigate the expressions of CD4+CD25+ T cells and IL-10 in the peripheral blood of patients with rheumatoid arthritis(RA) and its clinical significance.Methods:Flow-cytometric assay was employed to detect CD4+CD25+ T cells of thirty RA patients(RA group) and twenty normal controls(normal control group),and double antibody sandwich ELISA was applied to detect IL-10 in the serum from the two groups.Results:The levels of CD4+CD25+ T cells in RA group and normal control group were(12.5±8.4),(7.9±3.2)% respectively,with no statistics significance(t=2.132,P0.05);The levels of IL-10 were(12.4±10.5),(22.7±20.6) pg/ml respectively,with no statistics difference(t=2.920,P0.05).Conclusion:Cellular immunity destruction and defective function of CD4+CD25+ T cells was shown in RA.

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Key concepts: IL-2 receptor, Rheumatoid arthritis, Peripheral blood, Medicine, Immunology, Immunity, Clinical significance, Internal medicine