Pharmacokinetics studies of novel soybean iosflavone sulfonate in rats with HPLC

prodrug decision for novel soybean isoflavone sulfonate(DB) and study oral bioavailability of parent drug daidzein(DZ) in the prodrug were studied with HPLC.In the drug metabolism experiments,DZ were obviously detected in rat plasma after oral administration of DB.The results showed that the pharma cokinetic process of DZ was two compartment model after rats were ig given DB 50 mg/kg.The t1/2(h) was 7.86±3.60.The relative oral bioavailability of DZ in DB is only 26.8%.Although the relative oral bioavailability of parent drug DZ in prodrug did not achieve the desired improvement,the results show that DB is prodrug of DZ.