Expression of P_( 16 )Protein, Cyclin D_1 Protein and Rb Protein in Gastric Carcinoma Tissue and Its Biological Action

Objective To study the expression of P 16 protein, Cyclin D 1 protein and Rb protein in gastric carcinoma tissue and its relationship with biological action. Methods Using immunohistochemistry method, the expression of P 16 protein, Cyclin D 1 protein and Rb protein was detected in gastric mucosa from 10 normal specimens and 30 gastric carcinoma specimens, respectively, and was analyzed combined the clinical characteristics. Results The positive rates of P 16 protein, Cyclin D 1 protein and Rb protein were 90.00%, 10.00% and 90.00% in normal gastric mucosa, and 36.67%, 53.33% and 50.00% in gastric carcinoma tissue, respectively. There all existed significant differences in these three indexes between two groups. To some extent, they were associated with the differentiation degree of gastric carcinoma, lymph nodes metastasis and distant metastasis. Conclusion P 16 protein, Cyclin D 1 protein and Rb protein are associated with the occurrence of gastric carcinoma. The detection of them will be helpful to judge the prognosis of gastric carcinoma.