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Research on Chiral Separation of Sibutramine Hydrochloride Enantiomers with β-Cyclodextrin as Chiral Selector in HPLC Using Non-chiral Column

Wang Chaoyang

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Abstract

By adding β-cyclodextrin as chiral selector into mobile phase and in Sibutramine hydrochloride ,sibutramine hydrochloride enantiomers were separated using non-chiral C18 column in high performance liquid chromatography(HPLC).In the mobile phase composed of methano-H2O(50∶50,V/V ) containing 0.8 mmol/L β-cyclodextrin at pH=6,the two enantiomers were well separated in 5.7 minutes.The mechanism of chiral separation through adding chiral selector into mobile phase was also discussed.

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What this paper is about

By adding β-cyclodextrin as chiral selector into mobile phase and in Sibutramine hydrochloride ,sibutramine hydrochloride enantiomers were separated using non-chiral C18 column in high performance liquid chromatography(HPLC).In the mobile phase composed of methano-H2O(50∶50,V/V ) containing 0.8 mmol/L β-cyclodextrin at pH=6,the two enantiomers were well separated in 5.7 minutes.The mechanism of chiral separation through adding chiral selector into mobile phase was also discussed.

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Available abstract

By adding β-cyclodextrin as chiral selector into mobile phase and in Sibutramine hydrochloride ,sibutramine hydrochloride enantiomers were separated using non-chiral C18 column in high performance liquid chromatography(HPLC).In the mobile phase composed of methano-H2O(50∶50,V/V ) containing 0.8 mmol/L β-cyclodextrin at pH=6,the two enantiomers were well separated in 5.7 minutes.The mechanism of chiral separation through adding chiral selector into mobile phase was also discussed.

Key concepts: Enantiomer, Cyclodextrin, Chromatography, Chiral column chromatography, High-performance liquid chromatography, Chemistry, Chiral derivatizing agent, Phase (matter)

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