2007•Practical Clinical MedicineRequires access

Inhibitory Effect of Artemisinin on Hepatoma H22 Cells

Xueming Li

Abstract

Objective:To investigate the inhibition of artemisinin toward mouse H22 cells in vitro.Methods:Cell counting staining of trypan blue,MTT colouration and cell counting were used for detecting the effect of artemisinin on cells' vigor,proliferation and growth curve in vitro.Results:Artemisinin inhibited H22 cells' vigor,and the effect depended on the concentration(P0.05)or time(P0.05);Artemisinin inhibited H22 cells' proliferation and the effect was stronger when concentration was higher(P0.05)or time was longer(P0.05);Artemisinin showed effect on H22 cells' growth curve,which depended on concentration(P0.05).Conclusion:Artemisinin effectively inhibite H22 cells'vigor,proliferation and growth curve in vitro,which may be a simple,effective,and economical treatment for liver cancer.

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Key concepts: Artemisinin, In vitro, Medicine, Growth inhibition, Trypan blue, Cell growth, Pharmacology, Biology