Clinical analysis of serum SF increase in common healthy population in Huhehaote area

Objective To analyze the clinical characteristics of serum ferritin(SF)increase in common healthy people to provide better guidance suggestion for the clinical diagnosis and treatment of the SF increase crowd.Methods The cases with increased SF detected by the chemiluminescence immune method among the healthy individuals of physical examination in the physical examination center of this hospital from January 2008 to December 2012 were collected and performed the further related detection and follow up detection.According to follow up results,the causes of SF increase were clinically analyzed.Results In 600 cases of SF increase physical examination individuals,SF in benign and malignant lesions were(478.55±456.19)ng/mL and(796.95±566.93)ng/mL respectively,the difference between them had statistical significance(P0.05).In 72 cases of increased SF malignant lesions,SF in liver cancer,pancreatic cancer,lung cancer,lymphoma,leukemia,multiple myeloma and cervical cancer were(996.35±599.93),(746.35±544.67),(556.72±448.61),(438.62±488.43),(516.11±422.68),(477.42±379.25),(468.34±422.99)ng/mL respectively,the differences between liver and pancreatic cancer groups with other groups had statistical significance(P0.05),but the difference among lung cancer,lymphoma,leukemia,multiple myeloma and cervical cancer groups had no statistical significance(P0.05);in 528 cases of SF increase benign lesions,SF in digestive,respiratory,endocrine,hematology,nervous,cardiovascular,renal system lesions were(789.33±446.49),(488.70±414.28),(61.53±299.79),(300.72±147.58),(556.74±458.71),(467.74±345.56),(263.45±168.45)ng/mL respectively,the differences between the digestive system group with other system groups had statistical significance(P0.05).The increased levels of SF had difference among digestive and other systems(P0.05);in 265 cases of SF increase digestive system lesions,SF in viral hepatitis,liver cirrhosis after viral hepatitis,alcoholic hepatitis,liver cirrhosis after alcoholic hepatitis group were(656.33±346.56),(780.33±446.21),(456.34±278.96),(660.12±403.69)ng/mL respectively,the increased levels of SF had statistical difference between the viral hepatitis group and the alcoholic hepatitis group(P0.05).Conclusion SF can be used as one of the important reference laboratory indexes of malignant tumor early screening,but the specificity is not high,SF can be used as the auxiliary diagnosis of hepatocellular carcinoma in the patients with AFP negative.