Comparison of the delay effect of three drugs on diabetic cataract in rats

Objective To examine whether intraperitoneal injection of glucose can be used to successfully establish a rat model of sugar cataract,and to explore whether there are delay effect and short-term therapeutic effect of Baicalin eyedrop,taurine eyedrop,taurine intraperitoneal injection and intraperitoneal injection of vitamin C on the cataract models.Methods Eighty-four Sprague-Dawley rats aged 45 days,male to female ratio 1∶1,were used in this study.The rats were randomly divided into 6 groups,14 in each group.The cataract models were established using intraperitoneal injection of 30% glucose in a dose of 2.5 mL/time for male rats and 2 mL/time for female rats.All the drugs were administered at the same time,including eyedrops twice a day,and intraperitoneal injection of glucose once a day.Slit-lamp examination was performed to assess the lens changes from the third day of injection.The body weight and diet intake were recorded during the study.Results Rat models of sugar cataract were successfully established by intraperitoneal injection of glucose within 3 days.Delay effect and short-term therapeutic effect of each drug were observed with the same tendency,and their intensity was in an order of taurine intraperitoneal injection Baicalin eyedrop taurine eyedrop intraperitoneal injection of vitamin C.Conclusions Intraperitoneal injection of 30% glucose can induce sugar cataract in rats in a short period.Taurine injection and Chinese traditional medicine Baicalin eyedrop show a more distinct delay effect on the sugar cataract compared with taurine eyedrop and Vc injection.