Relationship Between N-terminal Probrain Natriuretic Peptide Level and Cardiac Function in Patients with Congestive Heart Failure

To study the relationship between N-temrina probarin natriuretic peptide(NT-proBNP) level and cardiac functions in patients with congestive heart failure(CHF),the plasma level of NT-proBNP in 108 patients with CHF and 30 healthy controls were measured by electrochemiluminescence immunoassay(ECLIA) and left ventricular ejection fraction(LVEF) was measured by echocardiography.The results showed that the NT-proBNP level in patients with CHF was significantly higher compared with healthy controls(P0.01).The NT-proBNP levels increased gradually with NYHA heart function classes increased by degrees(P0.01).There was negatively correlation between NT-proBNP level and LVEF(r=-0.633,P0.01).There was a good correlation between the plasma NT-proBNP level and cardiac function.The plasma NT-proBNP level could be as a biochemical marker of cardiac function in CHF patients.