2011•Chinese Journal of Gastroenterology and HepatologyRequires access
Expression and significance of β-catenin and APC in gastric adenoma and gastric cancer
Chang Liu
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Abstract
Objective To observe the expression of β-catenin and APC in normal gastric mucosa,gastric adenoma and gastric cancer tissues,so as to investigate their significance in the carcinogenesis and progression of gastric cancer.Methods One hundred and twenty-six gastric epithelial biopsy specimens diagnosed by histopathology were obtained,including 40 normal gastric mucosa,38 gastric adenomatous polyps(22 high-grade and 16 low-grade intraepithelial neoplasia) and 48 gastric cancer.Expression of β-catenin and APC were detected by avidin-biotin complex(ABC) immunohistochemical method.Results The abnormal expression rates of β-catenin and APC increased progressively from the normal control group to gastric cancer.The difference was statistically significant(P0.05).The correlation of β-catenin and APC in gastric cancer was significant,but it was uncorrelated in gastric adenomas.Conclusion β-catenin and APC play important roles in the carcinogenesis and progression of gastric cancer.The correlation of β-catenin and APC in gastric adenomas is pending and need further research.