Changes of hs-CRP,CatS level in acute coronary syndrome patients serum and clinical significance

AIM:To investigate the serum high sensitive creactive protein(hs-CRP),cathepsin S(CatS)level changes and clinical significance in acute coronary syndrome patients.METHODS:All patients were divided into acute coronary syndrome(ACS group,n=53)and control group(n=36).The levels of serum hsCRP and CatS in two groups were detected and compared before and after treatment.RESULTS:There were no significant difference of two groups in gender,age,smoking,diabetes,cerebral infarction,hypertension prevalence rate.The levels of serum CatS and hs-CRP in ACS group before treatment and control group were(0.51±0.03)nmol/L,(10.21±5.03)mg/L and(0.43 ± 0.04)nmol/L,(3.64 ± 1.87)mg/L,respectively;there were statistically significant differences(P0.05).After treatment,the levels of serum CatS and hs-CRP in ACS group were(0.45±0.06)nmol/L and(6.05±3.25)mg/L,compared with before treatment(0.51±0.03)nmol/L and(10.21±5.03)mg/L,which were significantly decreased,there were statistically significant differences(P 0.05).CONCLUSION:Changes of hs-CRP,CatS level in ACS patients suggest that hs-CRP and CatS may play an important role in acute coronary syndrome,CatS may possibly act as a new biomarker of ACS.