Variation of drug resistance of Proteus mirabilis isolated from urine

Objective To study the clinical distribution and drug resistance of Proteus mirabilis isolated from urine,and provide guidance for clinical application of drug. Methods Collected from 2008-2012 hospitalization and outpatient urine specimens were isolated 215 strains of Proteus mirabilis,adopting VITEK 2 Compact automatic analyzer for identification and drug sensitive test,WHONET 5.4 software was used for statistical analysis. Results In 2008,2009,2010,2011 and 2012,the seperation from shows that Proteus mirabilis were 26 strain( 12. 2%),26 strain( 12. 2%),36 strain( 16. 9%),55 strain( 25. 8%) and 72 strain( 33. 8%),respectively,a total of 215 strains. The drug resistance rate of Proteus mirabilis in 2008- 2012 to nitrofurantoin 90%,to amikacin and meropenem were lowest,both 0%,to levofloxacin from 2008 to 2011 year 50%,28. 1% in 2012; to piperacillin / tazobactam from 2008 to 2009 20%,and 2010 to 2012 annual 5%; to cefotetan,sulperazon 7%. Conclusion Proteus mirabilis separation rate from 2008 to 2012is in a growing trend,this trend reminds us that along with the extensive use of antibiotics clinically,make the hospital infection rate showed a trend of rising. During 2008-2011,the trend is rising,while in 2012,it start to decline. This may be related to our hospital carry out the Reasonable application of antibiotics strictly in recent years.