Clinical Observation on 196 Patients with Congestive Heart Failure Treated by Metoprolol Combined with Losartan Potassium

Objecive To investigate the efficacy of metoprolol combined with losartan potassium on patients with congestive heart failure(CHF).Method On the basis of conventional treatment,196 cases of CHF patients were randomly divided into three groups:65 cases in metoprolol(M) group,67 cases in losartan potassium(losartan,L) group and 64 cases in metoprolol auxiliaried losartan(M-L) group.The first dose of metoprolol was determined according to heart function,if there were no adverse reactions,their weekly dose was doubled until the maximum tolerance.Losartan potassium was given,25~100mg,qd.The treatment course of three groups were all six months.Before and after treatment,the changes of cardiac function,left ventricular end-diastolic dimension(LVD),left ventricular end-systolic dimension(LVS),left ventricular ejection fraction(EF),cardiac output(CO),cardiothoracic ratio(C/T) and norepinephrine(NE) in each group were observed.Results The therapeutic effect of M-L group was better than those of M group and L group.Conclusions For CHF patients,the combination therapy of metoprolol and losartan potassium is safe and effective.It can effectively improve the cardiac function and quality of life,it is worth promoting in clinic.