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Influence of bone morphogenetic protein microspheres on the proliferation and the expression of marrow stromal cell of canine

Peifu Tang

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Abstract

Objective To investigate the influence of bone morphogenetic protein microspheres on the proliferation and the expression of marrow stromal cell of canine.Methods Bone morphogenetic protein was enwrapped in the microspheres,which was prepared with PLA and PGA.The influences of bone morphogenetic protein microspheres on the proliferation,expression of type Ⅰ collagen of marrow stromal cell of canine were investigated by histochemistry and cell culture.Result Bone morphogenetic protein microspheres could significantly stimulate alkaline phosphatase activity and Ⅰ collagen staining increased,but had no effect on the marrow stromal cell proliferation in vitro culture.Conclusion Bone morphogenetic protein can increase the osteogenic capacity of marrow stromal cell in vitro with the micropheres made of PLA and PGA as the carrier.

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What this paper is about

Objective To investigate the influence of bone morphogenetic protein microspheres on the proliferation and the expression of marrow stromal cell of canine.Methods Bone morphogenetic protein was enwrapped in the microspheres,which was prepared with PLA and PGA.The influences of bone morphogenetic protein microspheres on the proliferation,expression of type Ⅰ collagen of marrow stromal cell of canine were investigated by histochemistry and cell culture.Result Bone morphogenetic protein microspheres could significantly stimulate alkaline phosphatase activity and Ⅰ collagen staining increased,but had no effect on the marrow stromal cell proliferation in vitro culture.Conclusion Bone morphogenetic protein can increase the osteogenic capacity of marrow stromal cell in vitro with the micropheres made of PLA and PGA as the carrier.

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Available abstract

Objective To investigate the influence of bone morphogenetic protein microspheres on the proliferation and the expression of marrow stromal cell of canine.Methods Bone morphogenetic protein was enwrapped in the microspheres,which was prepared with PLA and PGA.The influences of bone morphogenetic protein microspheres on the proliferation,expression of type Ⅰ collagen of marrow stromal cell of canine were investigated by histochemistry and cell culture.Result Bone morphogenetic protein microspheres could significantly stimulate alkaline phosphatase activity and Ⅰ collagen staining increased,but had no effect on the marrow stromal cell proliferation in vitro culture.Conclusion Bone morphogenetic protein can increase the osteogenic capacity of marrow stromal cell in vitro with the micropheres made of PLA and PGA as the carrier.

Key concepts: Stromal cell, Bone morphogenetic protein 2, Bone morphogenetic protein, Bone marrow, Bone morphogenetic protein 5, Bone morphogenetic protein 7, In vitro, Chemistry

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