Influence of Pidotimod on the Changes of Peripheral Blood T Lymphocyte Subsets for Children with Recurrent Respiratory Tract Infection and its Curative Effects

Objective: To study the clinical effect of Pi do Maude on the treatment of the recurrent respiratory tract infection for children and to explore its influence on the changes of peripheral blood in T lymphocyte subsets. Methods: 160 cases with repeated respiratory tract who were treated in our hospital were selected and divided into the study group and control group with 80 cases in each one. The patients in the control group were treated by antibiotics, antipyretic, relieving cough and phlegm, the asthma and other symptomatic treatment, while the patients in the study group were treated by the pidotimod besides of the conventional methods. Then the changes of T lymphocyte subsets and clinical efficacy of two groups with peripheral blood were observed and compared. Results:After the treatment, the total efficiency in the study group was significantly better than that of the control group(P0.05). The levels of CD3+, CD4+, CD4+/ CD8+levels were higher than those of the control group with statistically significant differences(P0.05). There was no statistically significant difference about the white blood cell count and neutrophil levels of patients in the study group after the treatment(P0.05). There was no statistically significant difference between two groups(P0.05). The symptoms of children, which included the cough, fever, wheezing, pulmonary and antibiotic drug use in the study group were significantly less than those of the children in the control group(P0.01). There was no incidence of adverse reaction in the two groups. Conclusion: It is suggested that the Pidomaude could be well promoted in the treatment of recurrent respiratory infection for children which would effectively improve the immune function of T lymphocytes.