2005•Unpublished venueRequires access
Effects of interstitial cells of Cajal in stomach on diabetic gastroparesis
Hongtao Shi
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Abstract
Objective To clarify the effects of interstitial cells of Cajal in stomach on diabetic gastroparesis.Methods Rats were randomly divided into diabetic group and control group. Time of gastric emptying was measured and the tissue of antrum was observed through electrictelescope after establishing diabetic rat model for 3 months.Results Time of gastric emptying in diabetic rats was significantly longer than that of normal rats. The number of the gap junction of interstitial cells of Cajal in antrum of diabetic rats decreased significantly, and the rested structures were damaged;the organelles were also damaged; vacuoles were formed.Conclusion It is possible that changes of ultrastructural characteristics of interstitial cells of Cajal in stomach are one of the mechanisms of gastroparesis in diabetic rats.