EFFECT OF WEICHANGSHU ON PATHOLOGIC CHANGES OF GASTRIC INTERSTITIAL CELLS OF CAJAL OF RATS’ WITH DIABETIC GASTROPARESIS

Objective: To study the effects of weichangshu and medicine interfering in blood flow on gastric interstitial cells of Cajal pathologic changes of rats with diabetic gastroparesis.Methods: 131 male rats were randomly divided into 5 groups, normal, model, ethamsylate, lumbrukinase and weichangshu groups. Rats were interperitoneal streptozotocin(60mg/kg) once to make models except normal group. Each group was given corresponding medicine after modeling 10 days once a day, normal and model groups were given the same dose distilled water. Blood sugar, FINS, C-P and gastric emptying rate were determined, the number and immunoreaction intensity of gastric interstitial cells of Cajal were observed by immunohistochemistry method and light microscope, the ultrastucture of gastric interstitial cells of Cajal was examined by electron microscope.Results: The number and immunoreaction intensity of gastric interstitial cells of Cajal in model group were decreased and attenuated, the gastric interstitial cells of Cajal degenerated, the number of cell connection between gastric interstitial cells of Cajal was decreased. Weichangshu and lumbrukinase could abate the pathologic injury of gastric interstitial cells of Cajal, the number and immunoreaction intensity of gastric interstitial cells of Cajal in the two groups were respectively increased and enhanced, the number of cell connection between gastric interstitial cells of Cajal was increased. Ethamsylate made the pathologic injury of gastric interstitial cells of Cajal worse, menifested the number of gastric interstitial cells of Cajal was less, the number of cell connection between gastric interstitial cells of Cajal was reduced more significantly(P0.05).Conclusion: Weichangshu can lower blood sugar, improve gastric interstitial cells of Cajal pathologic changes and advance gastrointestineal motility.