Hemodynamic change caused from milrinone combined trimetazidine treatment for congestive heart failure

Objective:To observe hemodynamic change caused from milrinone combined trimetazidine treatment for congestive heart failure(CHF).Methods:A total of 125 CHF patients were randomly divided into routine treatment group(n=40),milrinone group(n=42,received milrinone based on routine treatment)and milrinone+trimetazidine group(n=43,received milrinone combined trimetazidine based on routine treatment),and 10d was regard as a course of treatment.Curative effect and changes of indexes were observed in all groups before and after treatment.Results:Clinical total effective rate of milrinone+trimetazidine group(88.3%)was significantly higher than that of routine treatment group(65.0%),P0.05all.Compared with routine treatment group and milrinone group after treatment,there were significant increase in stroke volume[SV,(49±8.1)ml,(54.4±8.2)ml vs.(61.5±8.2)ml],cardiac output[CO,(4.3±0.6)L/min,(4.7±0.5)L/min vs.(5.7±0.7)L/min],cardiac index[CI,(3.2±0.8)L·min-1·m-2,(3.6±0.5)L·min-1·m-2vs.(4.2±0.6)L·min-1·m-2],left ventricular ejection fraction[LVEF,(42.2±8.2)%,(47.6±8.2)% vs.(52.8±8.1)%]and transmitral early diastolic peak flow velocity/late diastolic peak flow velocity[E/A,(1.0±0.3),(1.2±0.2)vs.(1.4±0.3)]in milrinone+trimetazidine group,P0.05all.Conclusion:Milrinone combined trimetazidine therapy can significantly improve heart function in patients with congestive heart failure.