Study of cognition activated regional cerebral blood flow diversity in mild depression

[Objective] To investigate cognition activated regional cerebral blood flow(rCBF) diversity in mild depression patients using SPECT semiquantitative analysis.[Methods] SPECT imaging was performed on 12 mild depression patients and 12 matched healthy volunteers.All subjects performed cognitive task in the first day and basic task in the third day.Variation of rCBF in depression and control group was analyzed with ROIs method under the conditions of basic and cognitive task.[Results] Compared with the basic state,rCBF of healthy volunteers was significantly increased in right frontal lobe(0.996±0.094 vs 0.942±0.047) and left basal ganglia(1.094±0.103 vs 1.038±0.049) after cognition activation.P value was set at 0.05 level.There wasn't significant difference between cognition and basic state in mild depression group.[Conclusions] We can find light diversity of rCBF in depression through the cognition activated test,which could make for biological study and early diagnosis to depression.