The result analysis of second trimester prenatal screening in Changzhou city

【Objective】 To investigate and analyze the prenatal screening/diagnosis in Changzhou.【Method】 By DELFIA,serum AFP and f-βHCG level of 24 408 pregnant women were detected.And high-risk women were diagnosed by amniotic fluid cytology.【Results】 ①Among 24 408 pregnant women,1 268 cases were high risk.The positive rate was 5.19%.②648 cases were accepted amniotic fluid cytology,and the rate was 59.50%.③13 cases of fetal chromosomal abnormalities were found,of which 3 cases of Down syndrome,2 cases of trisomy 18,1 case of trisomy 13,and 29 cases were fetal chromosome polymorphism.④441 didn't need to accept amniotic fluid for prenatal diagnosis.After tracking follow-up,there were 18 cases adverse pregnancy happened.⑤In 5 years,there were 3 cases who were false negative,the rate was 0.1‰.【Conclusions】 Second trimester prenatal screening/diagnosis is to prevent birth defects and improve the birth quality.