2006•Practical Preventive MedicineRequires access

Study of Normal Value Ranges for Hematology and Biochemical Indexes in Male and Female SD Rats

Chen Zhi-lian

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Abstract

Objective To explore the normal value range variations for hematology indexes and biochemical indexes in serum of male and female SD rats.Methods The data of hematology indexes and biochemical indexes in serum of 586 rats in 3 experiments were collected and statistically analyzed.Results The average value and the 95% normal value range of ?hematology indexes and 10 serum biochemical indexes showed no significant difference between both sexes.No significant difference was found in RBC(P>0.05).But significant differences were found in WBC and AST in female rats(P<0.05),and no difference was found in male rats.The ALB and TG of male rats showed significant differences(P<0.05),but not in fe- male rats.Conclusions The normal value ranges of hematology and serum biochemical indexes in serum of SD rats(be- fore the test)are consistent with those literatures reported,and it is feasible to combine the female and male rat's data during statistical analysis.

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Objective To explore the normal value range variations for hematology indexes and biochemical indexes in serum of male and female SD rats.Methods The data of hematology indexes and biochemical indexes in serum of 586 rats in 3 experiments were collected and statistically analyzed.Results The average value and the 95% normal value range of ?hematology indexes and 10 serum biochemical indexes showed no significant difference between both sexes.No significant difference was found in RBC(P>0.05).But significant differences were found in WBC and AST in female rats(P<0.05),and no difference was found in male rats.The ALB and TG of male rats showed significant differences(P<0.05),but not in fe- male rats.Conclusions The normal value ranges of hematology and serum biochemical indexes in serum of SD rats(be- fore the test)are consistent with those literatures reported,and it is feasible to combine the female and male rat's data during statistical analysis.

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Available abstract

Objective To explore the normal value range variations for hematology indexes and biochemical indexes in serum of male and female SD rats.Methods The data of hematology indexes and biochemical indexes in serum of 586 rats in 3 experiments were collected and statistically analyzed.Results The average value and the 95% normal value range of ?hematology indexes and 10 serum biochemical indexes showed no significant difference between both sexes.No significant difference was found in RBC(P>0.05).But significant differences were found in WBC and AST in female rats(P<0.05),and no difference was found in male rats.The ALB and TG of male rats showed significant differences(P<0.05),but not in fe- male rats.Conclusions The normal value ranges of hematology and serum biochemical indexes in serum of SD rats(be- fore the test)are consistent with those literatures reported,and it is feasible to combine the female and male rat's data during statistical analysis.

Key concepts: Hematology, Internal medicine, Significant difference, Medicine, Physiology, Hematology analyzer, Biology, Endocrinology

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