THE EFFECT OF EARLY ENTERAL NUTRITION ON THE ACUTE INFLAMMATORY REACTION IN SEVERE ACUTE PANCREATITIS IN RATS

Objective To study the influence of early enteral nutrition (EEN) and total parenteral nutrition (TPN) on the acute inflammatory reactions in severe acute pancreatitis (SAP), and evaluate the effect of early EEN support on SAP in rats.Methods Sixty male SD rats were randomly assigned into EEN group, TPN group and sham operated (S) group. SAP model was set up for EEN and TPN groups. Transitional enteral nutrition, TPN or normal chew was given for 2 weeks to the three groups, respectively. The death rates and pathological changes of pancreas were observed, and the serum levels of amylase, CRP, IL 1β, IL 6 and TNF α were also detected.Result 1. No significant differences showed between the death rate or serum amylase level of EEN group and that of TPN group (p0.05, either). The pathological changes of pancreas of the two groups were similar. 2. The serum levels of CRP and IL 6 were significantly lower in EEN group than those in TPN group (p0.05, both), but no significant difference showed between the serum levels of TNF αor IL 1β of the two groups (p0.05, either).Conclusion EEN support does not increase the acute inflammatory reactions in pancreas or systemically, but can effectively decrease the infection rate and the severity of infectious inflammation in SAP rats.