Effects of glutamine combined with early enteral nutrition on severe acute pancreatitis' systemic inflammation

Objective To study the glutamine combined with early enteral nutrition's effects on severe acute pancreatitis' systemic inflammation. Methods 150 Cases with severe acute pancreatitis were divided into total parenteral nutrtion group(TPN group), early enteral nutrition group(EEN group) and Glutamine and early enteral nutrition group(G+EEN group) according to their therapeutic methods. The curative effects, APACHEⅡ score and liver and kidney function were compared after treatment. Inflammatory cytokines of hs-CRP, TNF-α, IL-1 β, IL-6, IL-8 and IL-10 before and after treatment were detected and compared. Results The efficiency rate in G+EEN group was significantly better than that in TPN and EEN group(P0.05), with lower APACHEⅡ score and better liver and kidney function. The level of hs-CRP, TNF-α, IL-1 β, II-6 and IL-8 after treatment in G+EEN group were significantly lower than that in TPN and EEN group(P0.05), except IL-10, which was significantly higher than that in TPN and EEN group(P0.05). Conclusion Glutamine combined with early enteral nutrition could significantly ameliorate severe acute pancreatitis' systemic inflammation, its curative effects is better than early enteral nutrition and total parenteral nutrition.