The expression and value of tumor type M2 pyruvate kinase in the diagnosis of breast cancer

Objective: To investigate the expression and diagnostic values of tumor M2-PK(TuM2-PK) in breast cancer.Methods: The concentration of tumor M2-PK in plasma was detected by ELISA in 52 patients with breast cancer,36 patients with breast benign disease and 60 health controls.Results: TuM2-PK concentration in plasma and the positive rate were singificanfly higher in breast cancer(76.92%) than that in breast benign disease and in health controls(16.67% and 20.00%,respectively)(P0.01),TuM2-PK levels was higher in breast cancer patients with lymph node metastasis(81.25%) than that without metastasis(45.00%)(P0.05).Conclusion: The measurement of TuM2-PK is of great clinical value for the diagnosis of breast cancer,and is helpful in the evaluation of lymph node metastasis.