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Significance and expression of PTTG?bFGF in human prolactinomas

Guoxin Li

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Abstract

Objective: To investigate the expression of PTTG and bFGF in pituitary adenomas and their clinical significance.Methods: 43 pituitary adenomas were divided into the invasive group and the no-invasive group.Expressions of PTTG and bFGF protein were examined by immunocytochemical method;PTTG-mRNA was detected by RT-PCR method.Results: PTTG protein was significantly different between invasive and no-invasive group;the expression of PTTG-mRNA PTTG-mRNA level increased in invasive group;there was obviously positive correlation between PTTG and bFGF.Conclusions: PTTG and bFGF are correlated with invasiveness of pituitary adenomas and served as the molecule marker of invasive growth.

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What this paper is about

Objective: To investigate the expression of PTTG and bFGF in pituitary adenomas and their clinical significance.Methods: 43 pituitary adenomas were divided into the invasive group and the no-invasive group.Expressions of PTTG and bFGF protein were examined by immunocytochemical method;PTTG-mRNA was detected by RT-PCR method.Results: PTTG protein was significantly different between invasive and no-invasive group;the expression of PTTG-mRNA PTTG-mRNA level increased in invasive group;there was obviously positive correlation between PTTG and bFGF.Conclusions: PTTG and bFGF are correlated with invasiveness of pituitary adenomas and served as the molecule marker of invasive growth.

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Available abstract

Objective: To investigate the expression of PTTG and bFGF in pituitary adenomas and their clinical significance.Methods: 43 pituitary adenomas were divided into the invasive group and the no-invasive group.Expressions of PTTG and bFGF protein were examined by immunocytochemical method;PTTG-mRNA was detected by RT-PCR method.Results: PTTG protein was significantly different between invasive and no-invasive group;the expression of PTTG-mRNA PTTG-mRNA level increased in invasive group;there was obviously positive correlation between PTTG and bFGF.Conclusions: PTTG and bFGF are correlated with invasiveness of pituitary adenomas and served as the molecule marker of invasive growth.

Key concepts: Messenger RNA, Protein expression, Prolactinoma, Pituitary adenoma, Immunohistochemistry, Internal medicine, Biology, Andrology

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