Expression of pituitary tumor transforming gene (PTTG),bFGF and invasiveness of pituitary adenoma

Objective To detect messenger RNA (mRNA) expression of PTTG and bFGF in pituitary tumors, to explore the relationship between PTTG, bFGF mRNA expression and mvasiveness of pituitary adenomas, arid to investigate its clinical value. Methods PTTG and bFGF mRNA expression were determined in 19 invasive pituitary adenomas and 11 non-polymerase chain reaction (RT-PCR). The correlation between mRNA expression of PTTG and bFGF, the correlation between mRNA expression of PTTG, bFGF and tumor invasiveness were studied. Results Both mRNA expression of PTTG and bFGF increased in the invasive pituitary adenomas ( P 0.01). Conclusion Higher expression of human PTTG and bFGF correlates with tumor invasiveness. Enhanced PTTG expression could be an important factor involved in early pituitary tumor genesis. PTTG may play a role in pituitary invasiveness by up-regulating expression of the basic fibroblast growth factor (bFGF) and stimulating bFGF secretion so as to increase angiogenesis.