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NONINVASIVE ASSESSMENT OF ENDOTHELIUM-DEPENDENT VASODILATION IN HYPERTENSIVE PATIENTS

WU Lan-fen

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Abstract

Objective To study the endothelium-dependent vasodilation function in patients with essential hypertension (EH).Methods B-mode ultrasonography was used to measure the change in diameter of the brachial artery during reactive hyperemia and after sublingual administration of nitroglycerin in 26 patients with EH and 12 matched healthy subjects.Results Despite similar ages, blood lipid and glucose levels in 2 groups, the increased percentage of the brachial artery diameter was lower in patients with EH than that in normal controls (12.53%±4.26% vs 17.76%±6.02%, P0.01) during reactive hyperemia, whereas nitroglycerin-induced changes were similar (19.41%±6.73% vs 21.24%±6.96%, P0.05).Conclusion Impaired endothelium-dependent vasodilation function existed in patients with EH, while without other evidence of atherosclerosis.

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What this paper is about

Objective To study the endothelium-dependent vasodilation function in patients with essential hypertension (EH).Methods B-mode ultrasonography was used to measure the change in diameter of the brachial artery during reactive hyperemia and after sublingual administration of nitroglycerin in 26 patients with EH and 12 matched healthy subjects.Results Despite similar ages, blood lipid and glucose levels in 2 groups, the increased percentage of the brachial artery diameter was lower in patients with EH than that in normal controls (12.53%±4.26% vs 17.76%±6.02%, P0.01) during reactive hyperemia, whereas nitroglycerin-induced changes were similar (19.41%±6.73% vs 21.24%±6.96%, P0.05).Conclusion Impaired endothelium-dependent vasodilation function existed in patients with EH, while without other evidence of atherosclerosis.

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Available abstract

Objective To study the endothelium-dependent vasodilation function in patients with essential hypertension (EH).Methods B-mode ultrasonography was used to measure the change in diameter of the brachial artery during reactive hyperemia and after sublingual administration of nitroglycerin in 26 patients with EH and 12 matched healthy subjects.Results Despite similar ages, blood lipid and glucose levels in 2 groups, the increased percentage of the brachial artery diameter was lower in patients with EH than that in normal controls (12.53%±4.26% vs 17.76%±6.02%, P0.01) during reactive hyperemia, whereas nitroglycerin-induced changes were similar (19.41%±6.73% vs 21.24%±6.96%, P0.05).Conclusion Impaired endothelium-dependent vasodilation function existed in patients with EH, while without other evidence of atherosclerosis.

Key concepts: Reactive hyperemia, Brachial artery, Medicine, Vasodilation, Essential hypertension, Sublingual administration, Internal medicine, Cardiology

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NONINVASIVE ASSESSMENT OF ENDOTHELIUM-DEPENDENT VASODILATION IN HYPERTENSIVE PATIENTS — Research Paper | ScholarLens