Expression of COX-2 and p53 in NSCLC and its relationship with angiogenesis

Objective To investigate the expression of COX-2 and p53 in NSCLC and its relationship with tumor angiogenesis.Methods Eighty-five specimens of lung cancer and 20 specimens of lung benign lesion with complete clinical data were collected.Immunohistochemical method was used to examine COX-2 and p53 protein.Results (1)The positive rates of COX-2 and p53 expression in the NSCLC were 56.5% and 58.8% respectively,the MVD value in the NSCLC tissue was 43.55±11.45 and all of them were significantly higher than those in lung benign lesion;(2)The expression of COX-2 in NSCLC was positively correlated with histological type,differentiation degree and lymph node metastasis(P0.05);(3)The expression of p53 is positively related with lymph node metastasis(P0.05);(4)The MVD value in lung adenocarcinoma was higher than that in lung squamous cell cancer,and higher in NSCLC with lymph node metastasis than in NSCLC without lymph node metastasis(P0.05);(5)There was statistically significant correlation between expression of COX-2 and MVD,p53 and MVD,COX-2 and p53.Conclusion The high expression of COX-2 and p53 is involved in lung cancer development.COX-2 and p53 show a positive correlation in lung cancer angiogenesis.Combination detection of the two provides a new way to evaluate NSCLC clinically,besides,COX-2 and p53 can be potential therapy target of NSCLC in the future.