Applied research of hypertonic saline in intracranial hypertension

Objective To evaluate the effects of 23.4% Hypertonic saline used in patients with acute intracranial hypertension. Methods 15 patients who suffered with cerebral hemorrhage and had sign to have lateral ventricle drainage were divided into 2 groups randomly, 23.4% Hyperosmotic saline or 20% mannitol was used by vessel. Intracranial pressure (ICP), mean arterial pressure (MAP), central venous pressure (CVP), cerebral perfusion pressure (CPP), plasma electrolure and osmotic pressure were monitored from initiation of treatment to 6 hours flowing it. Results ICP was reduced (2.5±1.1) kPa (P0.01) when treated with 23.4% Hyperosmotic saline after (28±20) minutes and lasted for 3 hours, MAP was decreased as well; ICP was reduced (2.0±1.3) kPa (P0.01) when treated with 20% mannitol after (49±25) minutes and lasted for 1 hour. CVP, plasma electrolure and osmotic pressure had no difference between the two groups in 6 hours (P0.05). Conclusion 23.4% Hyperosmotic saline have more efficiency than 20% mannitol when treated in intracranial hypertension, can be selected to treat intracranial hypertension.