Comparison the treatment of 7.5% hypertonic saline with 20% Mannitol in patients with intracranial hypertension

Objective To compare the effects and safety of 7.5% hypertonic saline with 20% Mannitol in patients with intracranial hypertension.Methods We presented 23 patients,all of whom was performed with internal ventricle drainage,and 7.5% hypertonic saline and 20% Mannitol was randomly used to lower intracranial hypertension.Baseline ICP(intracranial pressure)and ICP 30min,1 hour and 3 hours after administration was recorded though internal ventricle drainage.GCS at discharge was also recorded.Results Both groups had a similar dehydrating effect,and the latter had fewer effects on serum dielectrics.Conclusions 7.5% hypertonic saline has definitive dehydrating effects,and has less complication.