Application of Femoston in frozen embryo transfer cycle in patients with endometrial dysplasia

Objective:To investigate the relationship between embryo implantation outcome and serum estradiol(E_2) levels,endometrial thickness in patients with endometrial dysplasia in frozen embryo transfer cycles through hormone replacement therapy(HRT) with Femoston,and to analyze the effect of using the different dose and mode of 178 estradiol on serum E_2 levels,endometrial thickness and embryo planting outcomes.Methods:Forty-one frozen embryo transfer cycles through HRT with Femoston were retrospectively analyzed in patients with endometrial dysplasia who were canceled cycle due to thin endometrium through hormone replacement program with progynova.The relationship between serum E_2 levels and endometrial thickness was investigated in two groups including the implantation group and non-implantation group according to clinical outcome.All the patients were divided into three groups;group A(oral estrogen6 mg),group B(oral estrogen 4 mg+-vaginal estrogen 2 mg),and group C(oral estrogen 6 mg+vaginal estrogen 2 mg).The differences of their serum E_2 levels,endometrial thickness and pregnancy outcome were compared among the three groups.Results:There were no statistical difference in patients' age,infertile years,number of embryos transferred,high-quality embryos,basic E_2level,E_2 levels on transplant day and the third day after injection of progesterone,endometrial thickness on the seventh days after medication and the transplant day between embryo implantation group and non-implantation group(P 0.05).The endometrium was significantly thicker in implantation group than non-implantation group(P0.05).E_2levels on transplant day,E_2levels on the third day after injection of progesterone and endometrial thickness were significantly increased in group A compared with group B or C(P0.05).In addition to endometrial thickness to be significantly increased(P0.05),other indexes showed no significant differences in group C compared with group B.Conclusions:It is suitable for patients with endometrial dysplasia in frozen embryo transfer cycles through hormone replacement therapy with Femoston,and the serum E_2 levels,endometrial thickness and embryo implantation and clinical pregnancy rates could achieve satisfactory results.The endometrial thickness is an important factor to influence the frozen embryo transfer outcome.The administration of 17β estradiol by oral 4mg and vaginal 2mg is more suitable for the endometrial growth and embryo implantation.