Study on hormone replacement therapy for patients with poor endometrial growth to freezing-thawing embryo transfer

Objective To investigate the effects of hormone replacement therapy on endometrial thickness of different dosages and different duration of the patients with poor endometrial growth receiving oral estrogen in frozen-thawed embryo transfer cycles.Methods Retrospective analysis was performed on 97 frozen-thawed embryo transfer cycles of patients with poor endometrial growth treated with estrogen.Patients were divided into implantation group and non-implantation group based on clinical outcome to analyze the relation between embryo implantation outcome and endometrial thickness.Furthermore,the duration and dosage of estrogen were analyzed to detect the effects of different durations and dosages of estrogen on endometrial thickness.Results (1)It was observed that there was no statistical difference of the endometrial thickness in the estrogen application time and the day of deciding embryo transfer between the embryo implantation group and non-implantation group.However,the endometrial thickening value(thickness value of the day of deciding embryo transfer minus the value of the 12th day of estrogen treatment)of implantation group was significantly higher than that of non-implantation group(P0.05).(2)Compared with the 13-15 day group and 16-18 day group of the day of deciding embryo transfer,the endometrial thickness and endometrial thickening value of the 19-21 day group were significantly increased(P0.05),but there was no significance compared with the 22-24 day group(P0.05).(3)There was no significant different on the endometrial thickness and endometrial thickening value between the groups of taking 6 mg estrogen and 9 mg estrogen on the day of deciding embryo transfer(P0.05).Conclusions For patients with poor endometrial growth treated with estrogen for preparing endometria in freezing-thawing embryo transfer,the endometrial thickening value was one of the important factors for outcome of frozen-thawed embryo transfer.Taking the estrogen within 19-21 days was favorable for endometrial growth and embryo implantation,but increasing the dosage had no effect on endometrial growth.