The comparing research of domestic octreotide and loperamide in the treatment of acute diarrhea related pelvic radiotherapy

OBJECTIVE To explore and compare the potential efficacy of domestic octreotide and loperamide in the treatment of acute diarrhea related with pelvic radiotherapy.METHODS Fifty-nine patients with grade II or III diarrhea during pelvic radiotherapy were enrolled into this research.Twenty-six patients received the treatment of loperamide(initial dose 4 mg,po,and 2 mg q4h),and thirty-three patients were given the subcutaneous injection of domestic octreotide(100 g,tid).Their respective efficacy was justified after the continuous treatment for 5 days.RESULTS The complete remission rate of diarrhea in loperamide group was 34.6%,while that in domestic octreotide group was 66.7%,and P0.05.The proportion rate of patients' number with need for transfusion treatment and the duration of radiotherapy discontinuance in the two groups,were significantly different.The complete remission rate of diarrhea of octreotide injection if loperamide was ineffective was 70.6%,and that in octreotide ineffective cases of it was 45.4% if dose of octreotide was elevated.CONCLUSION The effective rate of domestic octerotide was significantly higher than that of loperamide in treating for acute diarrhea related with pelvic radiotherapy.Octreodie treatment could decrease the proportion rate of diarrhea patients who needed transfusion treatments and shorten the duration of radiotherapy discontinuance.For those patients with severe diarrhea,sooner using of octreotide or using octreotide in higher dose than common dose might be a more reasonable clinical choice.