Relationship of glycometabolism disturbance with plasma P-selectin and the severity of coronary artery lesions in acute coronary syndrome

Objective To investigate the changes of plasma level of P-selectin in patients with acute coronary syndromes(ACS)with or without glycometabolism disturbance and to determine the relationship of abnormality blood sugar with severity of coronary artery lesions in ACS cases.MethodsPlasma P-selectin level was detected by ELISA in 116 cases with ACS(40 with ACS alone,34 with ACS+IGT/IFG,and 42 with ACS+type 2 diabetes),26 with diabetes and 26 controls.The extent of coronary artery stenosis in ACS patients was evaluated by the classification standard of American Heart Association.Results Significantly increased plasma P-selectin level was found in patients with ACS as well as diabetes groups compaered with that in the controls.Plasma levels of P-selectin in patients with ACS+IGT/IFG and ACS+type 2 diabetes were higher than those in patients with ACS alone(P0.05).The incidence of multiple coronary artery lesions was higher in patients with ACS+IGT/IFG and ACS+type 2 diabetes and changes of coronary artery stenosis were also more severe than those in ACS group(P0.05).Conclusion The abnormal platelet activation exists in ACS patients with or without glycometabolic disorder.The extent and range of the lesions in coronary arteries in patients with ACS+IGT/IFG and ACS+type 2 diabetes are more significant than those in patients with ASC alone.Thus,ACS with glucometabolism disturbance may be predisposed to a poorer prognosis.