A comparison of tolerance between metoprolol andcarvedilol in patients with chronic heart failure

Objective:To compare the tolerance between metoprolol and carvedilol in patients with chronic heart failure(CHF).Method: One hundred and eighty-six CHF patients randomly received metoprolol or carvedilol from low dosage at the basis of regular regimen to the dosage which was increasingly added to target dose. Result: The patients treated with carvedilol were more easy to reach the target dosage and the time of adjusting dosage were shorter than those treated with metoprolol [( 2.1% ∶ 58.2%, P 0.01 and ( 46.7± 17.2)d ∶( 31.6± 9.4)d,P 0.01)].The average doses were ( 81.1± 33.5)mg/d in metoprolol group and( 34.9± 14.6)mg/d in carvedilol group. The decreases of heart the in metoprolol group was greater than in carvedilol group [( 16.2± 3.5)次/min ∶( 13.8± 4.1)次/min,P 0.01].Compared with metoprolol, patients treated with carvedilol showed larger decreases in SBP [( 14.4± 4.12)mmHg ∶( 12.9± 3.72)mmHg, P 0.05] and DBP [( 7.9± 2.96)mmHg ∶( 6.7± 2.56)mmHg,P 0.05].Conclusion:Both meteprolol and carvedilol had good tolerance in CHF patients. Metoprolol produced greater effect in HR but less effect in BP. Carvedilol was more easy to be added to the target dose than metoprolol.The time of adjusting dosage was shorter in carvedilol group than in metoprolol group.