Analysis of clinical effect of alprostadil combined benazepril treatment of diabetic renal proteinuria

Objective To study the clinical effect of alprostadil combined benazepril in the treatment of diabetic renal proteinuria. Methods 65 patients with diabetic renal proteinuria, who were treated in our hospital from July 2013 to February 2015, were selected and randomly divided into observation group(33 cases) and control group(32 cases). To compare the clinical effect, the content of 24 h urinary protein, 24 h urinary microalbumin excretive rate, and the situation of adverse reaction between control group which was treated with benazepril and observation group which was treated with alprostadil combined benazepril. Results The differences of total effective rate between observation group(93.94%) and control group(81.25%) was statically significant(P 0.05). The content of 24 h urinary protein, 24 h urinary microalbumin excretive rate of the two groups after treatment 8 weeks were obviously lower than which before treatment(P 0.05), and after treatment, which in observation group was obviously lower than which in control group(P 0.05). The differences of the total adverse reaction rate between observation group(6.06%) and control group(9.39%) were no statically significant compared with(P 0.05). Conclusion Alprostadil combined benazepril in the treatment of diabetic renal proteinuria has better clinical effect and lower adverse reaction.