Clinical Significance of C-reactive Protein in Patients Undergoing Maintenance Hemodialysis due to Uremia

Objective: To investigate the C-reactive protein level and its correlation with malnutrition, anemia and infection in patients undergoing maintenance hemodialysis due to Uremia. Methods:Sixty-eight patients on maintenance hemodialysis due to uremia were studied. Blood samples were collected on the same day on hemodialysis at fast and the levels of Hb, Hct, TF, TP, AIb, PA, and CRP were determined. The dose of rHuEPO was recorded, and the relation between CRP and rHuEPO was observed. Results: Within the group of serum CRP rising, the dose of rHuEPO and the rate of EPO/Het were larger than that within the group which have nomal CRP (P0. 01). The former had lower level of Hb,Hct and Alb than the latter(P 0.01). But age,sexual, weight and Kt/V have no significant difference. The level of CRP in infection group was higher than that in non- infection group significantly (P0. 01). The level of Hb , AIb and TF was lower than that in non- infection group significantly (P0. 01), The level of PA was lower than that in non- infection group significantly (P0. 05) ; but age, sexual and weight were no significant different, and the level of serum CRP had a negative relation with Hb (P0. 01). The level of CRP had a negative correlation with the level of Hb,AIb,PA and TF(P0. 01). Conclusion:The level of CRP rises popularly a-mong the patients undergoing maintenance hemodialysis due to uremia, and the rising of CRP can predict the effect of rHuEPO ideally. The level of CRP can reflect the anemia, malnutrition and inflammation reactions,there are certain relations between a-nemia, malnutrition and inflammation reactions.