Expression levels and clinical significance of PTEN and FHIT in epithelial ovarian tumors

Objective:To explore the expression levels and clinical significance of PTEN and FHIT in epithelial ovarian tumors.Methods:Surgical specimens in paraffin of 95 cases(51 cases of ovarian cancer,16 cases of borderline ovarian tumor,18 cases of benign ovarian tumors,10 cases of normal ovarian tissue) were collected,the expression levels of FHIT and PTEN were detected by immunohistochemical SP method.Results:FHIT expressed in 10 cases of normal ovarian tissue,18 cases of benign ovarian tumor and 16 cases of borderline ovarian tumor,the negative expression rate in ovarian cancer was significantly higher than those in benign ovarian tumor and borderline ovarian tumor(P0.05).There was significant difference in negative expression rate of FHIT protein between lymphatic metastasis group and non-lymphatic metastasis group(P0.05);negative expression rate of FHIT protein was not related to pathological types and clinical staging.The expression levels of PTEN protein in borderline ovarian tumor and ovarian cancer were significantly lower than those in benign ovarian tumor and normal ovarian tissue(P0.05).There was a positive correlation between PTEN protein expression and differentiation grades of ovarian cancer(P0.01),and there was a negative correlation between PTEN protein expression and clinical pathological staging(P0.05).Conclusion:Low expression levels and expression deletion of PTEN gene and FHIT gene play an important role in the oncogenesis,invasion and metastasis of ovarian cancer,combined detection of PTEN and FHIT contribute to early diagnosis,early treatment and assessment of biological behaviors.