2007•Zhongguo shiyan fangjixue zazhiRequires access

Pharmacokinetic Studies of Naringenin and Hesperetin in Human Plasma after Oral Administration of Zhizhu Wan

Wang Xi-jun, Xi Chen

Abstract

Objective:Elucidating the pharmacokinetic properties of Zhizhu Wan.Method:By using β-Glucuronidase,free hesperintin and naringenin were obtained from the hesperetin-glucronide naringenin-glucronaide in plasma,the contents of the two compounds in plasma was determined by HPLC.Results:T1/2(ka)/T1/2(ke)(h) for naringenin and hesperetin are 2.142±0.999/5.491±3.926 and 2.106±0.728/5.824±3.067 respectively,and the AUC(mg/L·h) value are 34.886±22.199 and 39.407±19.535 for naringenin and hesperetin respectively.Conclusion:The method for determinning naringenin and hesperetin in plasma has been established,and the pharmacokinetic parameters can be instructive for clinic apllication.

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Key concepts: Hesperetin, Naringenin, Pharmacokinetics, Chemistry, Pharmacology, Human plasma, Oral administration, Chromatography