The change of regulatory T cells level of peripheral blood in patients after joint replacement surgery and clinical significance

OBJECTIVE To explore the change of regulatory T cells level of peripheral blood in patients after joint replacement surgery and clinical significance.METHODS 278 cases of arthroplasty patients in our hospital from July 2008 to August 2011 were chosen,and 263 cases of arthroscopic treatment of non-joint replacement surgery patients at the same time were selected as the control group.The CD + 4 of CD25 + T cell rates were taken with flow cytometry for detection.RESULTS The rate of joint replacement surgery of CD + 4 of CD25 + T cells accounted for the CD + 4 T cells in patients after surgery were significantly increased,the difference was statistically significant(P﹤ 0.05).There was no significant difference for the control group before and after surgery(P﹥0.05).The percentage change of CD + 4 of CD25 + T cells for joint replacement surgery patients before and after surgery were(1.69 ± 1.23) %,it was significantly higher than that of the control group of(0.15 ± 1.27) %,the difference was statistically significant(P ﹤ 0.05).CONCLUSION The infection in arthroplasty has a relation with the immune response caused by prosthesis.The peripheral blood regulatory T cell levels may be one of the infection presence and severity indicator.