Level of the IL-6, IFN-γ、IL-5 in the Mice with Mycoplasma Pneumoniae Infection and the Effect of Clarithromycin Treatment on Cytokine Production

Objective:To observe the cytokine in the serum and bronchoalveolar lavage fluid of Mycoplasma Pneumonia mice and the effect of clarithromycin treatment on cytokine production.Methods:The Kunming mice were randomized into three groups.The three groups were normal group,infection group,treatment group.After infection,clarithromycin treatment group were treated with clarithromycin for five days(6 g·kg-1·d-1).On the 8th day,the IL-6,IFN-γ and IL-5 levels were determined in the serum and bronchoalveolar lavage fluid of each group.Results:The IL-6,IFN-γ and IL-5 levels were increased in the Pneumonia Mycoplasma infected group.A decrease of IL-6,IFN-γ levels were observed in the clarithromycin treatment group,but had no effect on the IL-5.Conclusion:The IL-6,IFN-γ and IL-5 levels were increased in the Mycoplasma Pneumonia mice.Clarithromycin treatment had effect on Mycoplasma Pneumonia infection.