Effect of Clarithromycin on IL-6,IFN-γ,IL-5 Levels in Mice with Mycoplasma Pneumoniae Infection

Objective To investigate the effect of clarithromycin on the cytokine production in mice with Mycoplasma pneumoniae( MP) infection. Methods Sixty Kunming mice were randomly divided into Group A1( mice without MP),Group A2( mice with MP) and Group A3( mice treated with clarithromycin). After the mice model of Mycoplasma pneumoniae infection was developed successfully in the Group A2 and Group A3,the mice in the Group A3 were treated with clarithromycin for five days. On the 8th day after the mice model was developed successfully,the interlenkin( IL)-6,interferon γ( IFN-γ) and IL-5 levels were detected in the serum and bronchoalveolar lavage fluid of mice among three groups. Results Compared with Group A1,the IL-6,IFN-γ and IL-5 levels in the serum and bronchoalveolar lavage fluid increased significantly in the Group A2 and GroupA3( P 0. 05). But the IFN-γ and IL-6 levels of mice in the Group A3 were lower than those in the Group A2( P 0. 05). IL-5 level showed no significant difference between Group A2 and Group A3( P 0. 05). Conclusion The IL-6,IFN-γ and IL-5 levels increase in the Mycoplasma Pneumonia mice. Clarithromycin may significantly reduce the IL-6 and IFN-γ levels of mice with Mycoplasma pneumoniae infection.