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Expression of vascular endothelial growth factor C in tongue cancer and its role in lymphatic metastasis and prognosis

Xiuqing Zhang

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Abstract

Objective To study the expression of VEGF-C in tongue cancer and its role in lymphatic metastasis and prognosis. Methods Paraffin-embedded specimens from 56 patients with tongue cancer were examined by immunohistochemical staining. Results Positive immunohistochemical staining for VEGF-C protion was observed in 22 of the 56 patients(39.3%). The VEGF-C antigen was identified in the cytoplasm of cancer cells. The expression of VEGF-C was notably higher in lymph-node-positive group than in node-negative group and was significantly associated with prognosis. Conclusion VEGF-C may play an important role in lymphatic invasion/metastasis and prognosis.

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What this paper is about

Objective To study the expression of VEGF-C in tongue cancer and its role in lymphatic metastasis and prognosis. Methods Paraffin-embedded specimens from 56 patients with tongue cancer were examined by immunohistochemical staining. Results Positive immunohistochemical staining for VEGF-C protion was observed in 22 of the 56 patients(39.3%). The VEGF-C antigen was identified in the cytoplasm of cancer cells. The expression of VEGF-C was notably higher in lymph-node-positive group than in node-negative group and was significantly associated with prognosis. Conclusion VEGF-C may play an important role in lymphatic invasion/metastasis and prognosis.

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Available abstract

Objective To study the expression of VEGF-C in tongue cancer and its role in lymphatic metastasis and prognosis. Methods Paraffin-embedded specimens from 56 patients with tongue cancer were examined by immunohistochemical staining. Results Positive immunohistochemical staining for VEGF-C protion was observed in 22 of the 56 patients(39.3%). The VEGF-C antigen was identified in the cytoplasm of cancer cells. The expression of VEGF-C was notably higher in lymph-node-positive group than in node-negative group and was significantly associated with prognosis. Conclusion VEGF-C may play an important role in lymphatic invasion/metastasis and prognosis.

Key concepts: Immunohistochemistry, Tongue, Lymphatic system, Medicine, Pathology, Lymph node metastasis, Vascular endothelial growth factor C, Cancer

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