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Significance of VEGF-C in non-small cell lung cancer with lymph node metastasis

Hui Zheng

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Abstract

Objective To study the relationship between VEGF-C expression and clinicopathologic characteristics of patients with non-small cell lung cancer(NSCLC). Methods VEGF-C and CD34 expressions were detected in 80 patients with NSCLC by immunohistochemical staining.The correlation of VEGF-C to microvessel density(MVD),histological type,differentiation and lymphatic metastasis were analyzed.Results The expression of VEGF-C correlated highly with histology,especially in adenocarcinoma(P=0.030 8) and lymphatic metastasis(P=0.024 6).The expression of VEGF-C protein was negatively related with the differentiation of NSCLC and MVD.Conclusion VEGF-C promotes intratumoral lymph angiogenesis and lymph node metastasis.The high expression of VEGF-C indicates high risk of lymphatic metastasis.

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What this paper is about

Objective To study the relationship between VEGF-C expression and clinicopathologic characteristics of patients with non-small cell lung cancer(NSCLC). Methods VEGF-C and CD34 expressions were detected in 80 patients with NSCLC by immunohistochemical staining.The correlation of VEGF-C to microvessel density(MVD),histological type,differentiation and lymphatic metastasis were analyzed.Results The expression of VEGF-C correlated highly with histology,especially in adenocarcinoma(P=0.030 8) and lymphatic metastasis(P=0.024 6).The expression of VEGF-C protein was negatively related with the differentiation of NSCLC and MVD.Conclusion VEGF-C promotes intratumoral lymph angiogenesis and lymph node metastasis.The high expression of VEGF-C indicates high risk of lymphatic metastasis.

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Available abstract

Objective To study the relationship between VEGF-C expression and clinicopathologic characteristics of patients with non-small cell lung cancer(NSCLC). Methods VEGF-C and CD34 expressions were detected in 80 patients with NSCLC by immunohistochemical staining.The correlation of VEGF-C to microvessel density(MVD),histological type,differentiation and lymphatic metastasis were analyzed.Results The expression of VEGF-C correlated highly with histology,especially in adenocarcinoma(P=0.030 8) and lymphatic metastasis(P=0.024 6).The expression of VEGF-C protein was negatively related with the differentiation of NSCLC and MVD.Conclusion VEGF-C promotes intratumoral lymph angiogenesis and lymph node metastasis.The high expression of VEGF-C indicates high risk of lymphatic metastasis.

Key concepts: Lung cancer, Adenocarcinoma, Immunohistochemistry, Pathology, CD34, Metastasis, Angiogenesis, Medicine

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