Clinical observation of Candesartan and Fosinopril in the treatment of diabetic nephropathy

Objective To observe the clinical effect of Candesartan combined with Fosinopril in the treatment of diabetic nephropathy (DN).Methods 60 cases with type 2 diabetes along with early nephropathy were randomly divided into 3 groups, which one was treated with Candesartan 4mg daily,another was treated with 10mg daily,and the combined therapy group was treated with Candesartan and Fosinopril.At the beginning and the end of treatment,the renal function,urinary albumin excretion rate(UAER)in 24 hours,and the mean arterial blood pressure(MAP)were measured.Results After 16 weeks treatment,the level of UAER decreased in all groups.More significant in combined group compared with the other two groups with single drug. No severe adverse reaction occured.Conclusion Combination of Candesartan and Fosinopril in the treatment of diabetic nephropathy can significantly decrease urinary protein,then prevent the development of DN,and improve the survival situation of DN patients.