Clinical Study of Gastric Dysmotility in Patients with Gastroesophageal Reflux Disease

Objective To investigate the behavior of gastromyoelectric in patients with gastroesophageal reflux disease(GERD),and the effect of gastromyoelectric in pathogenesis of GERD.Methods 65 patients with GERD were randomly chosen in this study.30 healthy volunteers were selected as normal control.All the patients and volunteers underwent fasting and postprandial electrogastrogram(EGG) examination.Patients with GERD were divided into 2 groups according to the result of gastroscopy:reflux esophagitis(RE) group and non-erosive reflux disease(NERD) group.The prevalence of gastric dysrhythmias were compared between the two groups.19 patients with gastric dysrhythmia underwent the second EGG examination after one week's treatment.The EGG parameters were analyzed before and after the treatment.Results Compared with the control group,dominant frequency(DF),DF in normal range(N%) and postprandial to fasting power ratio(PR) were obviously decreased,especially after test meal(P0.05 or 0.01).Gastric electrical rhythm in GERD was disordered,and mainly displayed as bradyastria.The clinical symptoms were alleviated or disappeared in our clinical trial.At the same time,the EGG parameters of 19 patients with gastric dysrhythmia were significantly improved after the therapy(P0.5 or 0.01).The prevalence of postprandial gastric dysrthythmia were 71.9% in RE group and 60.6% in NERD group.But,there was no statistical difference(P0.5).Conclusion There were abnormal preprandial and postprandial gastric electrical activities in patients with GERD.Gastric dysrhythmia may play an important role in the pathogenesis of GERD.Electrogastrogram can provide guide for diagnosis in GERD.