Pituitary adenoma:retrospective analysis of 128 cases

Objective To study clinical,biological behavior,immunohistochemical and endocrinological characters of pituitary adenoma. Methods A total of 128 cases of pituitary adenoma were investigated clinically.PRL,GH,ACTH,TSH,LH and FSH were examined by ABC immunocytochemical method. Results All the cases of pituitary adenoma classified by immunohistochemistry were as follows:17.2% were nonhormonal adenoma,37.5% were monohormonal adenoma,including 7 cases of prolactin adenoma,12 cases of growth hormonal adenoma,14 cases of adrenocorticotropic hormonal adenoma,15 cases of other hormonal adenoma,25.0% were double hormonal adenoma and 20.3% were multiple hormone-expression adenoma including three kinds of hormones and more. Conclusion Immunohistochemical results are not always consistent with clinical manifestations.Other mechanism may participate into the hyperprolactinemia of non-prolactin-expression pituitary adenoma apart from compression effect of tumors.Based on the results of immunohistochemistry,it can conclude that pituitary adenoma is of diversity and complexity.