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2006•Zhongliu fangzhi yanjiuRequires access

Expression and Relationship between CD44 and Ki-67 in Invasive Pituitary Adenoma

Bo Duan

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Abstract

Objective To study the expression and role of CD44 and Ki-67 in invasive pituitary adenoma and the relationship between them.Methods The expression of CD44s、CD44v5 and Ki-67 in 20 cases invasive pituitary adenoma and 18 cases non-invasive pituitary adenoma were detected with SP immunohistochemical technique.Results The expressive levels of CD44s and Ki-67 in the invasive pituitary adenomas were significantly higher than those in the non-invasive ones(P(0.01)),it is positively correlation between them.The expression levels of CD44v5 in the invasive and non-invasive pituitary adenomas has no difference.Conclusion CD44s and Ki-67 correlated with invasiveness of pituitary adenoma,they cooperated and play a important role in occurrence and progression of pituitary adenoma.They may be an objective biological marker for diagnose and estimating prognosis of invasive pituitary adenoma.

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What this paper is about

Objective To study the expression and role of CD44 and Ki-67 in invasive pituitary adenoma and the relationship between them.Methods The expression of CD44s、CD44v5 and Ki-67 in 20 cases invasive pituitary adenoma and 18 cases non-invasive pituitary adenoma were detected with SP immunohistochemical technique.Results The expressive levels of CD44s and Ki-67 in the invasive pituitary adenomas were significantly higher than those in the non-invasive ones(P(0.01)),it is positively correlation between them.The expression levels of CD44v5 in the invasive and non-invasive pituitary adenomas has no difference.Conclusion CD44s and Ki-67 correlated with invasiveness of pituitary adenoma,they cooperated and play a important role in occurrence and progression of pituitary adenoma.They may be an objective biological marker for diagnose and estimating prognosis of invasive pituitary adenoma.

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Available abstract

Objective To study the expression and role of CD44 and Ki-67 in invasive pituitary adenoma and the relationship between them.Methods The expression of CD44s、CD44v5 and Ki-67 in 20 cases invasive pituitary adenoma and 18 cases non-invasive pituitary adenoma were detected with SP immunohistochemical technique.Results The expressive levels of CD44s and Ki-67 in the invasive pituitary adenomas were significantly higher than those in the non-invasive ones(P(0.01)),it is positively correlation between them.The expression levels of CD44v5 in the invasive and non-invasive pituitary adenomas has no difference.Conclusion CD44s and Ki-67 correlated with invasiveness of pituitary adenoma,they cooperated and play a important role in occurrence and progression of pituitary adenoma.They may be an objective biological marker for diagnose and estimating prognosis of invasive pituitary adenoma.

Key concepts: Pituitary adenoma, Immunohistochemistry, Adenoma, Pathology, CD44, Medicine, Internal medicine, Biology

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Expression and Relationship between CD44 and Ki-67 in Invasive Pituitary Adenoma — Research Paper | ScholarLens