Study on the Treatment of Idiopathic Pulmonary Fibrosis with Prednisone,N-acetylcysteine Combined Captopril

Objective To explore the clinical efficacy of prednisone,N-acetylcysteine(NAC) combined with Captopril(CPT) in the treament of idiopathic pulmonary fibrosis(IPF).Methods Thirty-three patients with IPF were randomly divided into three groups,prednisone was given in control group(n=12);prednisone and NAC were given in combined groupⅠ(n=11);prednisone,NAC combined with CPT were given in combined groupⅡ(n=10).The changes of arterial partial pressure of oxygen(PaO2),total lung capacity(TLC),vital capacity(VC) and diffusion capacity of carbon monoxide(DLco) in three groups were observed after administration for 6 months.Results The percentages that PaO2,TLC,VC,DLco accounting their predictive values in combined groupⅡ were significantly higher than those of combined groupⅠand control group after 6 months(F=3.956～7.642,allP0.05).Conclusion Prednisone,NAC combined CPT is effective,safty and easy to tolerant in the treatment of IPF.